Technology

Applications

Drug metabolism & pharmacokinetics

• measurement of rates of hepatic metabolic clearance of low/slow-clearing compounds
• metabolite generation/identification
• first-pass bioavailability
• animal study design: inter-species comparison

Predictive toxicology

• hepatotoxicity
• subacute and chronic toxicities
• multi-organ toxicities
• toxicogenomics

Secondary / tertiary screening

• evaluate efficacy of compound AND its active metabolites
• metabolic inactivation
• single-test efficacy, toxicity
• compound library evaluation
• create qSAR databases