Applications

Predictive Toxicology
•   hepatotoxicity
•   multi-organ toxicity
•   toxicogenomics

Drug Metabolism & Pharmacokinetics
•   human hepatic metabolic & biliary clearance
•   absorption / bioavailability
•   first-pass bioavailability
•   time-based metabolism (metabolomics)
•   animal study design: inter-species
                   comparison

Secondary / Tertiary Screening
•    evaluate efficacy of compound
                  AND its active metabolites
•    metabolic inactivation
•    single-test efficacy, toxicity
•    compound library evaluation
•    create SAR databases (in silico proteomics)