Beverly
Hills, CA (July 21, 2005)
Hurel Corporation ("Hurel") announced today
it has entered into a contract with Johnson & Johnson Pharmaceutical
Research & Development, L.L.C., ("J&JPRD") under
which J&JPRD becomes the first pharmaceutical company to enter
the Joint Scientific Collaboration ("JSC") being organized
by Hurel.
Under the agreement, J&JPRD will provide both scientific guidance
and funding as Hurel performs a one-year research and development
program aimed at validating its microfluidic, "in vivo-surrogate"
cell-based assay platform technology (please see below),
and readying Hurel's first product for general, commercial release.
Hurel is currently holding discussions with several additional
Fortune 50 pharmaceutical and consumer products firms that have
also expressed interest to enter and participate in the Joint
Scientific Collaboration. Hurel projects its JSC laboratory activities
to commence in the third quarter of 2005.
Mr. Robert M. Freedman, President and Chief Executive Officer
of Hurel Corporation, said, "Hurel's simple technology will
enable researchers to achieve experimental endpoints of dramatically
improved concordance with, and predictive relevancy to, the in
vivo performance of drugs in humans. Hurel's predictive accuracy
will afford greatly improved selectivity in promoting preclinical
drug candidates into animal studies, and as such Hurel will become
an important new technological substitute for animal testing.
I'd like to thank and congratulate J&JPRD in being the first
pharmaceutical research and development organization to join,
and thereby in enabling us to launch, the Hurel Joint Scientific
Collaboration."
Dr. Leslie Z. Benet, Professor of Pharmaceutical Sciences at UCSF
and Chairman of Hurel's Scientific Advisory Board, said, "At
present there are no simple, rapid preclinical tools to mimic
the in vivo interplay of enzymes and transporters. What
is needed is a simple flow-through assembly that must be amenable
to incorporating hepatocytes and enterocytes from animal species
but also, alternatively, from humans, and should be high-throughput.
Such a novel preclinical tool would provide great insights into
the ADME of new molecular entities, and expose the reasons for
the discordance often found between the ADME characteristics of
drug molecules across animal species versus humans. I
believe that Hurel is that novel preclinical tool. I am looking
forward to working with J&JPRD towards realizing Hurel's potential."
Hurel Corporation is the developer of patented, microfluidic "in
vivo-surrogate" assay platform technologies for cell-based
studies. Originally invented by Dr. Gregory Baxter (now Hurel's
CSO) and Prof. Michael Shuler at Cornell University, a Hurel®
device comprises a "biochip" on which reside a number
of separate but microfluidically interconnected compartments.
The different compartments contain cultures of living cells drawn
from and/or representing different organs or tissues of a living
animal. Microfluidic channels between the compartments permit
compounds and "blood surrogate" fluid to recirculate
as in a living system. The physical geometry of the system is
designed to simulate certain physiological parameters—drug
residence time, circulatory transit time, fluid-to-tissue volume
ratios, or others—so as to mimic relevant aspects of the
physiology of the living animal.
The Company's initial product—a microfluidic circuit that
models real-time protein binding, metabolism, and extraction in
the liver—will comprise the world's first comprehensive,
in vitro test of first-pass liver bioavailability in
humans or other species. Other Hurel applications slated for early
development include devices customized for studying various multi-organ
toxicities (e.g., liver/lung or liver/cardiac), as well as for
studying the integrated mechanisms of absorption and bioavailability
of orally administered compounds.